SAN DIEGO — A freeway crash near the U.S.-Mexico border left at least one person dead Wednesday afternoon, the California Highway Patrol said.

The crash happened shortly before noon on southbound Interstate 805 near Camino De La Plaza, which is the last U.S. exit.

According to CHP’s Traffic Incident Information Page, a witness reported seeing a white sedan heading towards the port of entry make a U-turn on the freeway then hit a Honda minivan.

CHP confirmed that the driver of the white vehicle, an Audi, was driving the wrong-way at the time of the crash, hitting the van head on.

“Our understanding at this point is they turned around at the point of entry and came the wrong way,” CHP Sgt. Hope Maxson said.

It appeared the driver may have missed the last U.S. exit, and began driving the wrong way on I-805.

A Sig Alert was issued by Caltrans for the right two lanes on southbound I-805 north of Camino De La Plaza. The closure was expected to last several hours, according to CHP.

A man driving the minivan was killed as a result of the crash.

The driver of the Audi, a 29-year-old man, was transported to a nearby hospital with major, but not life-threatening injuries, CHP said.

Oncoming traffic on southbound I-805 was being directed to exit at Camino De La Plaza, CHP said.

You can check the latest traffic conditions and closures with the FOX 5 traffic map.

The San Diego County Medical Examiner’s Office was called out to the scene of the crash.

Crews with San Diego Fire-Rescue Department and with the Cities of Chula Vista and National City were also on scene.

The incident is still under investigation and the identity of both men involved the crash have not yet been publicly released.

Maxson added that drivers should be aware there is another option to turn back into the U.S.

“If you have missed the last U.S. exit here on the freeway, you can continue off to the left all the way down and there is a sign there that says U-turn back into U.S.A.,” Maxson said.

CHP also wants drivers to be aware of some ways to help protect yourself against wrong-way drivers. 

 “The safer place to be is normally the middle lanes because it tends to be that wrong-way drivers stick to the fast lane or the slow lane or the shoulders,” Maxson said. “The best thing to do is drive at a safe speed and keep a high visual horizon, looking as far down the freeway as you can.”