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SAN DIEGO — One person was killed and four others were seriously hurt Tuesday in a wrong-way crash on Interstate 5 in the Carmel Valley area.

The crash was reported at 12:50 a.m. on southbound I-5 north of Interstate 805. California Highway Patrol says a 42-year-old man was driving a Dodge Magnum northbound in the southbound lanes of I-5 when the Dodge collided with a white Honda Civic. A third vehicle, a Ford pickup driven by a 32-year-old man, also crashed into the Dodge.

A 52-year-old female passenger in the Honda was killed in the crash, according to CHP. Four other people had serious injuries, including another passenger and the driver of the Honda. The drivers of the Dodge Magnum and Ford pickup also suffered major injuries.

CHP said it’s not yet known if alcohol or drugs were a factor in the crash.

I-5 was closed for several hours and traffic was diverted to the bypass lanes as officers investigated. All lanes reopened at 6 a.m.