Stay in the heart of the Gaslamp Quarter all while getting lost… in Margaritaville. Margaritaville Hotel San Diego is the area’s newest hotel and the first urban Margaritaville on the West Coast. It’s the perfect combination of SoCal Cool and Island Vibes. From the restaurants and bars to the pool and beautiful rooms, you’ll want to book a staycation to check in and chill out.