The attack on Manomet Street near Gloria Street was reported around 7:20 p.m. Wednesday, San Diego police Lt. Manny Del Toro said. Investigators determined a man stepped out of a late 1990s burgundy Honda Accord or a similar vehicle, fired several gunshots, then sped away.
Responding officers found a 39-year-old man who had suffered a chest wound in the street, Del Toro said. Paramedics kept the man alive as he was transported to a hospital, but he later died. His name was withheld pending family notification.
The second victim was also taken to a hospital to be treated for a gunshot wound, but his injury was not life-threatening, Del Toro said.
Police described the gunman as black, about 6 feet 3 and wearing a dark hooded sweatshirt and dark pants. He was last seen heading east on Manomet Street in the small burgundy sedan.
Anyone with additional information on the shooting was asked to call San Diego police at 619-531-2000 or Crime Stoppers at 888-580-8477.