Around 1:15 a.m., nearly 30 firefighters from several agencies and San Diego County Sheriff's Department deputies hurried to the fire that broke out in the 700 block of South Grade Road.
The fire was so bright and high, 9-1-1 calls came in from more than a mile away, according to Alpine Fire Chief Bill Paskle.
The homeowner, David Bruce, has lived in the main home just feet away from the fire on South Grade Road for over 60 years.
Bruce says his tenant, Angel Rice, and her daughter's boyfriend, Cody, passed away. Bruce said the family dog Ricky also wasn't able to make it out.
Bruce also said Angel's husband, John, and daughter Brittney escaped the home and were taken to UCSD Medical Center
Firefighters say there was potential for the fire to spread to neighboring homes, had it not been for the family's pet goat.
"The house where the fire took place there was a goat in the yard. And the goat had cleared a lot of the vegetation away from the house....so I think that contributed to keeping the fire out of the vegetation," said Paskle.
The fire did sneak its way to some parts of the vegetation though. More than half a day after the fire started, flying embers began burning parts of a tree 40 feet above the ground. Crews worked to cut it down to put out the fire.
Bruce watched the firefighters closely for hours, fearing the fire that took away so much would flare again.
"They were nice people. They brought me supper nearly every night since they moved in last year," said Bruce.
One firefighter suffered injuries. They were so minor, he was able to continue battling the fire.
It's still unclear how the fire started.