The crash on Silver Strand Boulevard, about two miles south of the Hotel del Coronado, occurred around 7:45 a.m., according to SDPD Officer Matt Tortorella.
Paramedics took both officers to UCSD Medical Center, he said. As of Monday evening, one of the officers was listed in serious condition.
At the time of the crash, the officers were escorting a motorcade for the Slovakian President Andrej Kiska, who is visiting San Diego for economic talks with local officials.
President Kiska also experienced an incident Sunday night at the Loews Coronado Bay Resort when he and other people became trapped inside a second floor elevator. It took San Diego Fire-Rescue Department crews over an hour to rescue.