The woman died at the scene shortly after she was hit at about 7:40 a.m., police said.
Helicopter video showed a body covered by a yellow tarp in the 10800 block of Clairemont Mesa Boulevard. A silver sedan with front-end damage was stopped in the street.
The driver waited for police, who blocked off the street in both directions near De Portola Middle School during their investigation.
The name of the victim was not immediately released.