The home-invasion robbery in the 4200 block of Noyes Street was reported around 6:30 a.m., according to San Diego police.
Two victims were in the apartment at the time of the robbery but neither was injured, police said.
Police described one of the thieves as a black man in his late 20s to early 30s, last seen wearing all black clothing and a ski mask. The other was described as white or Hispanic, 5 feet 9 and 220 pounds, last wearing black clothing, a baseball hat and bandana.
No arrests have been made.