One female child was found with injuries, officials said. That girl's condition was unknown.
All of the children discovered at the home near Loganville, about 30 miles east of Atlanta, appear to be under age 10, officials said. The male victim was in his mid-30s.
The call came in shortly before 5 a.m., Gwinnett County police said.
"This is a horrendous crime not only for the victims but for the extended family, neighborhood and community," police said. "We are hoping and praying that the remaining victim survives his/her injuries and makes a full recovery."