At 5 p.m., a group of around 40 protesters, gathered on Broadway at Horton Plaza for a "Love Trumps Hate Solidarity" rally.
Around 8 p.m., the group grew as demonstrators started marching near Fifth and Island Avenues in the Gaslamp. Protesters were heard chanting anti-Trump slogans and carrying signs.
Police detained a few protesters. No injuries were reported.
Warning: This video contains graphic language.
A prayer vigil was also held Wednesday evening at a church in Hillcrest.