The northbound moving truck crashed off the State Route 163 bridge above Interstate 805 shortly after 5 p.m.
According to the California Highway Patrol, the 2015 Isuzu box truck was rear ended by a 2013 Ford Focus and the 22-year-old truck driver lost control before plowing through the guard rail and going over the side. The vehicle came to rest in roadside vegetation and began burning.
Three men in their work vehicle stopped to help after they saw the truck fall on the embankment. R.J. Paglino, Trevor Jackson and Jacob Pitman ran up the embankment and pulled the two passengers to safety.
"We pulled the female out first, followed by the male. We got them roadside and about 30 seconds after we pulled them out, the truck blew up and was engulfed in flames," said Paglino.
Medics took them victims to Sharp Memorial Hospital with minor to moderate injuries, according to CHP Sgt. Todd Maxson.
The burning truck set some nearby brush ablaze before firefighters put out the flames. The accidents led to lane closures on the northbound 805 and 163, causing heavy traffic until about 8 p.m.