The former first lady and secretary of state arrived in a small motorcade escorted by two San Diego police cars at about 9:30 a.m. She walked quickly from her car and disappeared into the rear entrance of the Jacobs' home.
The ticket prices for what the campaign is billing as a "Conversation with Hillary'' are $1,000 and $2,700, the maximum individual contribution for a candidate seeking his or her party's nomination under federal law.
The breakfast event is the next-to-last stop on a four-day, five-state fundraising trip that began Tuesday with events in Colorado in Aspen and Denver, according to the website PoliticalPartyTime.org, which tracks political fundraisers.
"She’s extremely intelligent, thoughtful and willing to be very clear about her position," said Susana Flaster.
Flaster and 3 other friends attended the brunch together.
"She was spectacular, very experienced, especially when she spoke about foreign policy," said Flaster.
Outside the Jacobs home, veteran Andres Wong gathered with protestors to tell Clinton she didn't belong in the White House.
"She’s being very less than forthright, if you’re going to have a commander in chief, then you have to have someone who’s very forthright," said one protestor who wanted remain unidentified.
"We need to wake up America, we need to wake up our leadership," said Wong.
Wong said Clinton's leadership failed when it came to her handling of the 4 Americans who died in Benghazi.
"She didn’t do anything to help those four people, she even prevented the help to come to those people," said Wong.
Those who attended the brunch said Hillary has their vote.
"Even more than she did before," said Flaster
"I think she has a great chance and I hope she makes it, I believe in her," said Gad Shannon, attendee.
Clinton was scheduled to be in Park City, Utah; Portland, Oregon; and Atherton in Northern California on Wednesday. She conducted fundraisers in San Francisco and Los Angeles on Thursday in her quest to become the nation's first female president.
After the event in La Jolla, Clinton is scheduled to fly to McAllen, Texas.
Irwin Jacobs was a major financial backer of President Barack Obama's presidential campaigns. Jacobs contributed more than $2 million to super PACs that supported Obama in 2012 and $23,000 directly to Obama and the Democratic Party, according to the political news website Politico.
This will be the 67-year-old Clinton's first visit to San Diego since she declared her candidacy. She was last in the city in June 2014, when she signed copies of her book, "Hard Choices,'' and later spoke at a biotech conference.
In Los Angeles on Thursday, Clinton met with a group of home care providers, praising the work they do and the contributions they make to the nation's health care system, and conducted a campaign fundraiser.
Clinton took part in a roundtable discussion on home care at Los Angeles Trade-Technical College organized by the Service Employees International Union, which includes members in the health care industry and is working to unionize more of them.
"The work that you're doing actually saves Medicaid,'' Clinton said.
"Because if people don't go into nursing homes or other kinds of long- term institutional settings, if they can stay in their home, you're actually doing a service that should be both recognized and respected as well as provide the argument for greater financial benefits for the caregivers.''
Some of the workers who attended the event said they want to ensure they are paid a living wage.
"The best part of my job is providing services to those in need in the comfort of their home,'' home-care worker Regina Sutton said. "We need to ensure that these jobs pay living wages and that the people who need our services can afford them.''
Clinton has pledged to defend President Barack Obama's health care law, reduce health costs, slow the growth of overall health care costs, deliver better care to patients and ensure that the savings benefit families.
"Hillary Clinton's actions speak louder than her empty rhetoric on issues that matter to everyday Americans,'' said Ninio Fetalvo, a Republican National Committee deputy press secretary.
"Clinton can't escape the fact that the failed `Obamacare' law she undyingly supports will continue to cause millions of dollars in cuts to home health agencies.''
Clinton on Thursday also attended a $2,700 per person fundraiser at the Brentwood home of music industry talent manager Scooter Braun and his wife, Yael. Braun discovered pop star Justin Bieber.
As she did in her previous Los Angeles-area fundraisers, Clinton discussed her commitment to being a champion for everyday Americans and outlined the "four fights'' that are the focus of her campaign -- building an economy of tomorrow; strengthening America's families; defending America and its core values; and revitalizing democracy, according to a campaign aide who spoke on the condition of anonymity.
Reality television personality Kim Kardashian West and her third husband, rapper Kanye West, were among the approximately 225 people in attendance.
Kim Kardashian West tweeted a photo of herself, her husband and Clinton, declaring, "I got my selfie!!! I really loved hearing her speak & hearing her goals for our country! #HillaryForPresident.''