Clinton, who is considering a run for president in two years, will later join Gov. Jerry Brown on stage during a luncheon at the Biotechnology Information Organization conference at the San Diego Convention Center.
She has come under criticism over the past couple weeks for commenting that she and former President Bill Clinton were in debt when they left the White House because of legal bills, without noting pending multimillion-dollar book deals and other prospects that would benefit them financially.
On Monday, Bill Clinton defended his wife’s commitment to the poor and said she was not out of touch.
The controversy arose from reports that the Clintons charge appearance fees around $200,000. A spokeswoman for the BIO conference did not respond to a question of how many Hillary Clinton was being paid for speaking at the luncheon.
CNN reported that the book tour for her memoir has resembled a political campaign, run by campaign operatives instead of book publicists.
“Hard Choices” includes her views on the attack in Benghazi, Libya, that killed four Americans, including three San Diegans. She also discusses her dealings with Russian President Vladimir Putin.