The burglary in the 6300 block of Elsberry Street was reported shortly before 3 a.m., according to San Diego police Officer Frank Cali.
The burglar entered the home through a sliding glass door located on a second-floor balcony, he said.
A man who lives in the home with his wife woke up to the sounds of the break-in and chased the burglar outside, firing off one round from a handgun into the air, Cali said. No loss was reported.
Police searched the area but were unable to find the burglar.