One suspect was possibly wounded in his chest or back at the Wells Fargo branch at Genesee Avenue and Nobel Drive around 5 p.m. and left the area in a blue or green Honda, possibly an Accord with a second suspect.
Authorities told Fox 5, the injured suspect made it to a local hospital and was being treated for his injuries.
San Diego police said a security guard fired a weapon twice. It was unknown if anyone else was injured in the shooting.
No other details were immediately available.