The crash on the highway at Marron Valley Road was reported at 5:40 p.m., according to the California Highway Patrol.
One person died at the scene, and a helicopter was dispatched to fly two critically injured people to a hospital, Cal Fire Capt. Mike Mohler said.
A fourth person involved in the crash sustained minor injuries and would likely be hospitalized as well, Mohler said.
CHP officers requested that the highway’s lanes be shut down in both directions.